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Enhance the quality of life for humankind by providing innovative and trusted ingredients to the healthcare industry. Qualtra Pharmaceuticals strives the best by meeting the technological and scientific needs of the society, government & industry . DENTOSOFT * Naturals For those individuals who prefer something natural for their teeth, there are many types of herbal toothpastes on the market. Herbal dental products are made from natural ingredients and some are even certified as organic. There is absolutely no difference in texture or consistency of these toothpastes when compared to the conventional toothpaste currently available on the market. However, the two major differences between natural toothpastes and the other toothpaste are the color and flavor. Most natural toothpastes do not look pristine white but have a range of colors. These toothpaste many not appear appealing initially but they function just as great and keep the teeth clean for a long time. The other distinct difference about natural toothpastes is their flavor. Consumers have started to switch over to natural toothpastes chiefly because they want natural ingredients. All regular tooth pastes come with many different synthetic chemicals, dyes and artificial flavors. With the herbal products, all you get are natural herbs and plant extracts. Dentosoft® uses 'concentrated' rare herbs and oils so effectively for soothing troubled gums, protecting teeth and adding 'extended' freshness all through the day. Recognizing the power of nature's gifts, we a natural based, herbal toothpaste which has been manufactured using extracts and oils of natural ingredients that helps you maintain your oral hygiene. Ingredients of Dentosoft® contains extracts of Neem, Clove, Babool, Majuphal, Catechu and other rare herbs and natural extracts. It has oils of coriander, ginger, lemon, and spearmint among other essential natural oils.
Azadirachta indica commonly known as Neem,an ingredient in Dentosoft ®Natural Toothpaste is an evergreen tree It possesses anti-bacterial, anti-cariogenic, anti-helminthic, anti-diabetic, anti-oxidant, astringent, anti-viral, cytotoxic, and anti-inflammatory activity. Nimbidin, Azadirachtin and nimbinin are active compounds present in Neem which are responsible for antibacterial activity. Neem bark is used as an active ingredient in a number of toothpastes and toothpowders. Neem bark has anti-bacterial properties, it is quite useful in dentistry for curing gingival problems and maintaining oral health in a natural way. Neem twigs are used as oral deodorant, toothache reliever and for cleaning of teeth. The objective of this article is to focus on the various aspects of Azadirachta indica in dentistry in order to provide a tool for future research. Neem in (Dentosoft ®Natural )is a natural antibacterial agent. Various scientific studies have revealed its antibacterial activity A clinical study demonstrated the effects of the leaf aqueous extract from Azadirachta indica (Neem) on adhesion, cell surface hydrophobicity and biofilm formation, which may affect the colonization by Candida albicans. The results suggest that Neem leaves have a potential anti-adhesive effect on the sample studied in vitro
Aqueous extract of Neem stick and the gallotannin-enriched extract fromMelaphis chinensis inhibited insoluble glucan synthesis and results in bacterial aggregation. It reduces the ability of streptococci to colonize tooth surfaces. Neem oil in Dentosoft ®Natural shows significant antibacterial activity and has been suggested for use in treating dental plaque.Mucoadhesive dental gel containing Azadirachta indica is found to be beneficial in reducing the plaque index and salivary bacterial count comparatively better than chlorhexidine gluconate mouthwash
The primary acid-tolerant bacteria associated with dental plaque including Streptococcus mutans, Streptococcus oralis, Streptococcus sobrinus, Lactobacillus acidophilus, Streptococcus salivarius, Streptococcus mitis, Streptococcus sangui, Streptococcus intermedius, and Streptococcus anginosus that surround orthodontic appliances are a common problem in many patients undergoing orthodontic treatment. It has also been reported that presence of fixed orthodontic appliance greatly inhibits oral hygiene and creates new retentive areas for plaque and debris. Ethanolic leaf extract of Azadirachta indica in Dentosoft ®Natural shows significant antibacterial activity against selected acidogenic oral bacteria causing dental plaque in fixed orthodontic appliance patients. The study conducted by clinicians evaluated the anti-plaque activity of the extract against S. mutans, S. sanguis, and S. mitis. The extract did not inhibit L. acidophilus when tested.
Brushing with Neem Dentosoft ®Natural toothpaste after every meal and using a mouthwash with Neem extract is recommended treatment for preventing gingivitis. In a study, Neem- Dentosoft ®Natural based mouth rinse was given to patients for assessing anti-plaque and anti-gingivitis activity. The findings conclude that Neem Dentosoft ®Natural mouth rinse is as effective as chlorhexidine in reducing periodontal indices. Neem stick is found to be effective as a toothbrush in reducing dental plaque and gingival inflammation. Studies indicate that leaf extract of A. indica-based mouth rinse is highly efficacious and that it may be used as an alternative therapy in the treatment of periodontal disease. Gingivitis has been prevented or even reversed with regular use of Neem toothpaste and mouthwash. Indica containing Azadirachtin) as an antimicrobial agent and the effective concentration of Soluneem required to inhibit periodontopathic bacteria and to compare it with a known antiplaque agent chlorhexidine (0.2%) in vitro. Study revealed that soluneem extract did not show activity against the organisms (Bacteroids fragilis, B. distatonics, Prevotella corporis, Prevotella melagingogenica, Pepto streptococcus species)
Sodium hypochlorite has been used as root canal irrigant for decades; it causes potential weakening of the tooth structure by decreasing the hardness and structural integrity of the dentin within the root canal. To overcome this disadvantage herbal drugs are used effectively to inhibit E. faecalis that causes root canal failure in patients undergoing endodontic treatment. Aqueous and ethanolic extract of Neem leaf inhibits S. mutans and E. faecalis which cause root canal failure in endodontic procedure. Its antioxidant and antimicrobial properties makes it a potential agent for root canal irrigation as an alternative to sodium hypochlorite. Literature suggested that the Neem (Azadirachta indica) leaf extract has significant antimicrobial effect against E. faecalis derived from infected root canal samples. The extract was found to be efficacious compared with 2% sodium hypochlorite. Regular brushing with Neem-containing Dentosoft ®Natural toothpaste will reduce the deposition of plaque, prevents caries, and enhances the immune response for overall oral health. Frequent usage of mouthwash Dentosoft ®Natural containing Neem extract will lessen gingival problems, and also treats halitosis. In this modern, trendy world, we have done enough damage to nature. It is high time we start changing ways, to synchronize ourselves with nature, providing ample space for each other. Here we are trying to retrieve and learn the ancient Indian ways, which can still be infused into our fast-paced lives for a good effect, benefitting our future generations to come. This article hopes to lay a good solid base for further uses of one of nature's best gift—Neem in many more day-to-day functions. If education can be provided in dental and dental hygiene schools about the use of Neem-based Dentosoft ®Natural and also herbal oral care products, it would help our dentists treat patients more holistically.
Ocimum sanctum in (Dentosoft ®Natural) is equally effective in reducing plaque and gingivitis as Chlorhexidine. The results demonstrated a significant reduction in gingival bleeding and plaque indices in both groups over a period of 15 and 30 days.
M. elengi in Dentosoft ®Natural) is known for its strengthening property for teeth.
Piper Cubeba in Dentosoft ®Natural) helps avoid having dental cavities and is an effective local antibiotic.
Different kinds of cariogenic bacteria, the MIC of caesalpinia sappan lignum was between 5-10 mg x mL(-1), and the MIC of other herbs was above 20 mg x mL(-1). For the eleven kinds of predominant bacteria which normally involved in pulp periapical disease and periodontitis, the MIC of caesalpinia sappan lignum was below 0.062 5 mg x mL(-1), and the MIC of the terminalia chebula retz was between 10-20 mg x mL(-1), and the others were above 20 mg x mL(-1).(A Study) Based on these facts Caesalpinia has good role in controlling Cariogenic Bacteria .
The antibacterial activity of acacia arabica was assessed using fresh isolates and reference strains of Actinobacillus actinomycetemcomitans, Capnocytophaga spp.,Porphyromonas gingivalis, Prevotella intermedia and Treponema denticola. A fine aqueous suspension of gum was produced by sonication and then a soluble fraction isolated by centrifugation and membrane filtration. These preparations were incorporated into Columbia agar at doubling concentrations. Growth of P. gingivalis and P. intermedia cultures on the agar was inhibited by whole gum sonicate at concentrations of 0.5–1.0% w/v. Both species showed reduced susceptibility when horse blood was present in the agar. The gum soluble fraction did not inhibit growth of any bacterial culture. The effect of acacia on bacterial proteases was examined with cell sonicates from log phase broth cultures. Enzyme activities were determined by fluorimetric assay with various synthetic peptide substrates. Most protease activities reduced in the presence of 0.5% w/v gum sonicate, with the trypsin-like activities of P. gingivalis and P. intermedia proving most sensitive. The gum soluble fraction was nearly always less inhibitory than the sonicate. The action of acacia gum against suspected periodontal pathogens and their enzymes suggests that it may be of clinical value.
The main chemical constituents of Acacia Catechu (Dentosoft ®Natural) are catechin, epecatechin, epigallocatechin, epicatechin gallate, phloroglucin, protocatechuic acid, quarcetin, poriferasterol glucosides, lupenone, procyanidin, kaemferol,L-arabinose, D-galactose.D-rhamnose andaldobiuronic acid, afzelchin gum, mineral and taxifolin. The cutch and Katha (extract) possess astringent, cooling properties; and is commonly used in ayurvedic preparations..
TCommiphora Myrrha In Dentosoft ®Natural) has been found to have the antiinflammatory efficacy of these plants for dental use
The essential oil In Dentosoft ®Natural) from clove (Syzygium aromaticum) is used as a topical application to relieve pain and promote healing in herbal medicine and also finds use in the fragrance.. Clove oil has two major components, eugenol and β-caryophyllene, which constitute 78% and 13% of the oil, respectively. They are generally recognized as 'safe', but the in-vitro study here demonstrates cytotoxic properties of both the oil and eugenol, towards human fibroblasts and endothelial cells. Clove oil was found to be highly cytotoxic at concentrations as low as 0.03% (v/v) with up to 73% of this effect attributable to eugenol. β-caryophyllene did not exhibit any cytotoxic activity, indicating that other cytotoxic components may also exist within the parent oil.
Amomum subulatum in vitro antimicrobial activity of Amomum subulatum and Elettaria cardamomum fruit extracts were studied against Streptococcus mutans, Staphylococcus aureus, Lactobacillus acidophilus, Candida albicans and Saccharomyces cerevisiae. The acetone, ethanol and methanol extracts of the selected plants exhibited antimicrobial activity against all tested microorganism except L. acidophilus. The most susceptible microorganism was S.aureus followed by S.mutans, S.cerevisiae and C.albicans in case of Amomum subulatum while in the case of Elettaria cardamomum; S.aureus was followed by C.albicans, S. cerevisiae and S.mutans. The largest mean zone of inhibition was obtained with the ethanolic extract of A. subulatum and acetonic extract of E.cardamomum against Staphylococcus aureus (16.32mm and 20.96mm respectively). Minimum inhibitory concentrations (MIC) of the extracts were also determined against the four selected microorganisms showing zones of inhibition ≥10mm. This study depicts that ethanol and acetone extracts of fruits of Amomum subulatum and Elettaria cardamomum can be used as a potential source of novel antimicrobial agents used to cure dental caries.
Rinsing the mouth with Curcurma Zedoaria gives instant relief.,Massaging the aching teeth with roasted, Curcurma Zedoaria eliminates pain and swelling & relief from gingivitis and periodontitis.
The occurrence of dental caries is mainly associated with oral pathogens, especially cariogenic Streptococcus mutans. Preliminary antibacterial screening revealed that the extract of Myristica fragrans, widely cultivated for the spice and flavor of foods, possessed strong inhibitory activity against S. mutans. The anticariogenic compound was successfully isolated from the methanol extract of M. fragrans by repeated silica gel chromatography, and its structure was identified as macelignan by instrumental analysis using 1D-NMR, 2D-NMR and EI-MS. The minimum inhibitory concentration (MIC) of macelignan against S. mutans was 3.9 μg/ml, which was much lower than those of other natural anticariogenic agents such as 15.6 μg/ml of sanguinarine, 250 μg/ml of eucalyptol, 500 μg/ml of menthol and thymol, and 1000 μg/ml of methyl salicylate. Macelignan also possessed preferential activity against other oral microorganisms such as Streptococcus sobrinus, Streptococcus salivarius, Streptococcus sanguis, Lactobacillus acidophilus and Lactobacillus casei in the MIC range of 2–31.3 μg/ml. In particular, the bactericidal test showed that macelignan, at a concentration of 20 μg/ml, completely inactivated S. mutans in 1 min. The specific activity and fast-effectiveness of macelignan against oral bacteria strongly suggest that it could be employed as a natural antibacterial agent in functional foods or oral care products.
Juglans regia L. bark is used in some countries as as a dye for coloring .. Its extract showed a broad spectrum antimicrobial activity in a dose dependent manner. It inhibited the growth of several species of pathogenic micro-organisms representing Gram-positive bacteria (Staphylococcus aureus and Streptococcus mutans), Gram-negative bacteria (Esherichia coli and Pseudomonas aeruginosa) and a pathogenic yeast (Candida albicans). The extract has either synergistic or additive action when tested with a wide range of antibacterial drugs. It also increased the pH of saliva. Thus, brushing the teeth with this bark may improve oral hygiene, prevent plaque and caries formation, and reduce the incidence of gingival and periodontal infections
The influence of the crude and active solvent fraction ofTrachyspermum ammi on S. mutans cariogenicity,. All the test groups showed reduction in caries (smooth surface as well as sulcal surface caries) in rats. Moreover, it also provides new insight to understand the mechanism influencing biofilm formation in S. mutans. Furthermore, the data suggest the putative cariostatic properties of T. Ammi and hence can be used as an alternative medicine to prevent caries infection.
Pistacia vera L., a member of Anacardiaceae family, has been used for sedation and analgesia in traditional medicine. In this study, the antinociceptive and anti-inflammatory effects as well as acute toxicity of the aqueous and ethanolic extracts of P. vera leaves were investigated in mice. The antinociceptive activity was studied using hot plate and writhing tests. The effect of the extracts against acute inflammation was determined using xylene-induced ear edema and the activity of the extracts, against chronic inflammation, was assessed using the cotton pellet test. The LD50 values of the infusion and maceration extracts were 0.8 g/Kg and 0.79 g/Kg, respectively. The aqueous and ethanolic maceration extracts of the P. vera leaves at the doses of 0.4 g/Kg and 0.5 g/Kg (IP), respectively, showed antinociceptive effects. The pretreatment of naloxone (2 mg/Kg, SC) inhibited the activities of extracts in hot plate test, but naloxone at the same dose could not inhibit the antinociceptive activity in writhing test. The extracts also showed anti-inflammatory effects in acute and chronic anti-inflammatory tests. The ethanolic extract was as effective as diclofenac in both inflammatory tests. The aqueous and ethanolic extracts of P. vera leaves demonstrated central and peripheral antinociceptive activities dose-dependently and the central effect may be mediated by opioid system. The extracts also demonstrated anti-inflammatory effects against acute and chronic inflammation
Pistacia vera L., a member of Anacardiaceae family, has been used for sedation and analgesia in traditional medicine. In this study, the antinociceptive and anti-inflammatory effects as well as acute toxicity of the aqueous and ethanolic extracts of P. vera leaves were investigated in mice. The antinociceptive activity was studied using hot plate and writhing tests. The effect of the extracts against acute inflammation was determined using xylene-induced ear edema and the activity of the extracts, against chronic inflammation, was assessed using the cotton pellet test. The LD50 values of the infusion and maceration extracts were 0.8 g/Kg and 0.79 g/Kg, respectively. The aqueous and ethanolic maceration extracts of the P. vera leaves at the doses of 0.4 g/Kg and 0.5 g/Kg (IP), respectively, showed antinociceptive effects. The pretreatment of naloxone (2 mg/Kg, SC) inhibited the activities of extracts in hot plate test, but naloxone at the same dose could not inhibit the antinociceptive activity in writhing test. The extracts also showed anti-inflammatory effects in acute and chronic anti-inflammatory tests. The ethanolic extract was as effective as diclofenac in both inflammatory tests. The aqueous and ethanolic extracts of P. vera leaves demonstrated central and peripheral antinociceptive activities dose-dependently and the central effect may be mediated by opioid system. The extracts also demonstrated anti-inflammatory effects against acute and chronic inflammation Foeniculum Vulgare In Dentosoft ®Natural) In Dental Fungal Infections Foeniculum Vulgare In Dental Fungal Infections showed antifungal property, with Punica granatum showing the highest inhibition of Candida albicans with a mean zone of inhibition of 22 mm. P-values 0.05 were obtained for Punica granatum when compared with the other extracts
PPiper nigrum, from which black pepper is derived, contains volatile oils, piperine, piperdine, chavicin and other active ingredients and is recognized as containing carminative and mildly antipyretic properties. In addition, it has been found to enhance the cleaning of teeth and to assist in the prevention of tooth disease. In this invention, piper nigrum is in the form of a powder
Triphala, green tea polyphenols and MTAD showed statistically significant antibacterial activity. The use of herbal alternatives as a root canal irrigant might prove to be advantageous considering the several undesirable characteristics of NaOCl. Terminalia Belerica in Dentosoft ®Natural) Dentosoft Helps maintain pH and manages Dental & Orall cavity infections well
Terminalia Chebula in Dentosoft ®Natural) is a ant caries herb thats especially very effective in young subjects
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